Transporters in Drug Development

Discovery, Optimization, Clinical Study and Regulation

Nonfiction, Health & Well Being, Medical, Specialties, Pharmacy, Science & Nature, Technology
Cover of the book Transporters in Drug Development by , Springer New York
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Author: ISBN: 9781461482291
Publisher: Springer New York Publication: September 16, 2013
Imprint: Springer Language: English
Author:
ISBN: 9781461482291
Publisher: Springer New York
Publication: September 16, 2013
Imprint: Springer
Language: English

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

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Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

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