Tumor Organoids

Nonfiction, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Tumor Organoids by , Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783319605111
Publisher: Springer International Publishing Publication: October 20, 2017
Imprint: Humana Language: English
Author:
ISBN: 9783319605111
Publisher: Springer International Publishing
Publication: October 20, 2017
Imprint: Humana
Language: English

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

More books from Springer International Publishing

Cover of the book Multibody Dynamics by
Cover of the book Basic Radiotherapy Physics and Biology by
Cover of the book Contagion, Isolation, and Biopolitics in Victorian London by
Cover of the book Classical and Modern Controls with Microcontrollers by
Cover of the book Comorbidity in Rheumatic Diseases by
Cover of the book Numerical Mathematics and Advanced Applications ENUMATH 2017 by
Cover of the book Pathology of Testicular and Penile Neoplasms by
Cover of the book Software Data Engineering for Network eLearning Environments by
Cover of the book Distributed Creativity by
Cover of the book Rethinking Engineering Education by
Cover of the book Nourishing Communities by
Cover of the book Narratives of Difference in Globalized Cultures by
Cover of the book Integrated Care for Complex Patients by
Cover of the book First Settlement of Remote Oceania by
Cover of the book SOA Maturity Model by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy