Angiogenesis and Anti-Angiogenesis in Hematological Malignancies

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Hematology, Oncology
Cover of the book Angiogenesis and Anti-Angiogenesis in Hematological Malignancies by Domenico Ribatti, Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Domenico Ribatti ISBN: 9789401780353
Publisher: Springer Netherlands Publication: January 6, 2014
Imprint: Springer Language: English
Author: Domenico Ribatti
ISBN: 9789401780353
Publisher: Springer Netherlands
Publication: January 6, 2014
Imprint: Springer
Language: English

It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.

More books from Springer Netherlands

Cover of the book Designing the Urban Renaissance by Domenico Ribatti
Cover of the book Trends in Teaching and Learning of Mathematical Modelling by Domenico Ribatti
Cover of the book The Ethics of Managed Care: Professional Integrity and Patient Rights by Domenico Ribatti
Cover of the book Pesticide Toxicity to Non-target Organisms by Domenico Ribatti
Cover of the book Paradise Postponed by Domenico Ribatti
Cover of the book The Rational as Reasonable by Domenico Ribatti
Cover of the book The Orchestration of the Arts — A Creative Symbiosis of Existential Powers by Domenico Ribatti
Cover of the book An Introduction to Neural Information Processing by Domenico Ribatti
Cover of the book Impetus and Equipoise in the Life-Strategies of Reason by Domenico Ribatti
Cover of the book Red Clover Science by Domenico Ribatti
Cover of the book Comparative Survey of Securities Laws by Domenico Ribatti
Cover of the book Demographic Change in Australia's Rural Landscapes by Domenico Ribatti
Cover of the book Stem Cells and Cancer Stem Cells, Volume 7 by Domenico Ribatti
Cover of the book Dielectric Properties of Isolated Clusters by Domenico Ribatti
Cover of the book Geomorphological Hazards in High Mountain Areas by Domenico Ribatti
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy