Genomic Architecture of Schizophrenia Across Diverse Genetic Isolates

A Study of Dagestan Populations

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics, Specialties, Internal Medicine, Neuroscience
Cover of the book Genomic Architecture of Schizophrenia Across Diverse Genetic Isolates by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Kazima Bulayeva, Oleg Bulayev, Stephen Glatt ISBN: 9783319319643
Publisher: Springer International Publishing Publication: November 17, 2016
Imprint: Springer Language: English
Author: Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
ISBN: 9783319319643
Publisher: Springer International Publishing
Publication: November 17, 2016
Imprint: Springer
Language: English

This book presents a long-term study in genetic isolates of indigenous small ethnics of Dagestan, located in the North-East part of Caucasus in Russia. Dagestan is characterized by extreme cultural and linguistic differences in a small geographic area and contains 26 indigenous ethnic groups. According to archeological data these indigenous highland ethnics have been living in the same area for more than ten thousand years. Our long-term population-genetic study of Dagestan indigenous ethnic groups indicates their close relation to each other and suggests that they evolved from one common ancestral meta-population. Dagestan has an extremely high genetic diversity between ethnic populations and a low genetic diversity within them. Such genetic isolates are exceptional resources for the detection of susceptibility genes for complex diseases because of the reduction in genetic and clinical heterogeneity. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. The book presents a study in four ethnically and demographically diverse genetic isolates with aggregation of schizophrenia that we ascertained within our Dagestan Genetic Heritage Research Project. The results obtained support the notion that mapping genes of any complex disease (e.g., schizophrenia) in demographically older genetic isolates may be more time and cost effective due to their high clinical and genetic homogeneity, in comparison with demographically younger isolates, especially with genetically heterogeneous outbred populations.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This book presents a long-term study in genetic isolates of indigenous small ethnics of Dagestan, located in the North-East part of Caucasus in Russia. Dagestan is characterized by extreme cultural and linguistic differences in a small geographic area and contains 26 indigenous ethnic groups. According to archeological data these indigenous highland ethnics have been living in the same area for more than ten thousand years. Our long-term population-genetic study of Dagestan indigenous ethnic groups indicates their close relation to each other and suggests that they evolved from one common ancestral meta-population. Dagestan has an extremely high genetic diversity between ethnic populations and a low genetic diversity within them. Such genetic isolates are exceptional resources for the detection of susceptibility genes for complex diseases because of the reduction in genetic and clinical heterogeneity. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. The book presents a study in four ethnically and demographically diverse genetic isolates with aggregation of schizophrenia that we ascertained within our Dagestan Genetic Heritage Research Project. The results obtained support the notion that mapping genes of any complex disease (e.g., schizophrenia) in demographically older genetic isolates may be more time and cost effective due to their high clinical and genetic homogeneity, in comparison with demographically younger isolates, especially with genetically heterogeneous outbred populations.

More books from Springer International Publishing

Cover of the book Towards Digital Enlightenment by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Electrohydrodynamic Patterning of Functional Materials by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Biliary Disease by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Agriculture and Ecosystem Resilience in Sub Saharan Africa by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Fuzzy Logic Augmentation of Neural and Optimization Algorithms: Theoretical Aspects and Real Applications by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Handbook of Genetic Programming Applications by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Cylindrical Liner Z-pinches as Drivers for Converging Strong Shock Experiments by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Pathology and Epidemiology of Cancer by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Parallel Problem Solving from Nature – PPSN XIV by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Social, Cultural, and Behavioral Modeling by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book The Metaphysics of Science and Aim-Oriented Empiricism by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Constitutional Politics and the Territorial Question in Canada and the United Kingdom by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Progress in Optomechatronic Technologies by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Fundamentals of Adaptive Signal Processing by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Cover of the book Self-Organized Quantum Dots for Memories by Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy