Lentiviral Vectors and Gene Therapy

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Genetics
Cover of the book Lentiviral Vectors and Gene Therapy by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson, Springer Basel
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson ISBN: 9783034804028
Publisher: Springer Basel Publication: March 22, 2012
Imprint: Springer Language: English
Author: David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
ISBN: 9783034804028
Publisher: Springer Basel
Publication: March 22, 2012
Imprint: Springer
Language: English

Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success.

This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success.

This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.

More books from Springer Basel

Cover of the book Influenza Vaccines for the Future by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book Human Medical Research by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book Genomics of Pattern Recognition Receptors by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book The Vexing Case of Igor Shafarevich, a Russian Political Thinker by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book Untranslated Gene Regions and Other Non-coding Elements by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book Alpine Treelines by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book Matrix Metalloproteinase Inhibitors by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book Galanin by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book Berichte zur Resistenzmonitoringstudie 2009 by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book Berichte zur Resistenzmonitoringstudie 2008 by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book Mathematics in the 21st Century by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book Variable Lebesgue Spaces by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book Proteases and Their Receptors in Inflammation by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
Cover of the book The Inflammasomes by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy