Mathematical Modelling of Chromosome Replication and Replicative Stress

Nonfiction, Science & Nature, Science, Biological Sciences, Biophysics, Physics, General Physics
Cover of the book Mathematical Modelling of Chromosome Replication and Replicative Stress by Jens Karschau, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Jens Karschau ISBN: 9783319088617
Publisher: Springer International Publishing Publication: July 11, 2014
Imprint: Springer Language: English
Author: Jens Karschau
ISBN: 9783319088617
Publisher: Springer International Publishing
Publication: July 11, 2014
Imprint: Springer
Language: English

DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive.

This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?.

A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive.

This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?.

A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.

More books from Springer International Publishing

Cover of the book Transmissions in Dance by Jens Karschau
Cover of the book Researching Entrepreneurship by Jens Karschau
Cover of the book The Driving Forces of Change in Environmental Indicators by Jens Karschau
Cover of the book Biomedical and Pharmaceutical Applications of Electrochemistry by Jens Karschau
Cover of the book Uncertainty Modeling by Jens Karschau
Cover of the book Nanomaterials for Fuel Cell Catalysis by Jens Karschau
Cover of the book Advances in Affective and Pleasurable Design by Jens Karschau
Cover of the book Public Choice Analyses of American Economic History by Jens Karschau
Cover of the book Recent Advances in Electrical Engineering and Control Applications by Jens Karschau
Cover of the book Rethinking the Individualism-Holism Debate by Jens Karschau
Cover of the book Postoperative Care in Thoracic Surgery by Jens Karschau
Cover of the book Israel's Exodus in Transdisciplinary Perspective by Jens Karschau
Cover of the book Cellular Injury in Liver Diseases by Jens Karschau
Cover of the book Web Services – ICWS 2018 by Jens Karschau
Cover of the book Innovative Web Applications for Analyzing Traffic Operations by Jens Karschau
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy