Principles of Asymmetric Synthesis

Nonfiction, Science & Nature, Science, Chemistry, Organic
Cover of the book Principles of Asymmetric Synthesis by Robert E. Gawley, Jeffrey Aube, Elsevier Science
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Robert E. Gawley, Jeffrey Aube ISBN: 9780080914138
Publisher: Elsevier Science Publication: May 29, 2012
Imprint: Elsevier Language: English
Author: Robert E. Gawley, Jeffrey Aube
ISBN: 9780080914138
Publisher: Elsevier Science
Publication: May 29, 2012
Imprint: Elsevier
Language: English

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis, this book presents a detailed analysis of the factors that govern stereoselectivity in organic reactions.

After an explanation of the basic physical-organic principles governing stereoselective reactions, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Practical Aspects of Asymmetric Synthesis" provides a critical overview of the most common methods for the preparation of enantiomerically pure compounds, techniques for analysis of stereoisomers using chromatographic, spectroscopic, and chiroptical methods.

The authors then present an overview of the most important methods in contemporary asymmetric synthesis organized by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions, one chapter on reductions, and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). This organization allows the reader to compare the leading methods for asymmetric synthesis in an appropriate context.

A highlight of the book is the presentation and discussion of transition states at the current level of understanding, for important reaction types. In addition, extensive tables of examples are used to give the reader an appreciation for the scope of each reaction. Finally, leading references are provided to natural product synthesis that has been accomplished using a given reaction as a key step.

  • Authoritative glossary to aid understanding of stereochemical terminology
  • Explanations of the key factors influencing stereoselectivity with numerous examples, organized by reaction type
  • A handy reference guide to the literature of asymmetric synthesis for practitioners in the field
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis, this book presents a detailed analysis of the factors that govern stereoselectivity in organic reactions.

After an explanation of the basic physical-organic principles governing stereoselective reactions, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Practical Aspects of Asymmetric Synthesis" provides a critical overview of the most common methods for the preparation of enantiomerically pure compounds, techniques for analysis of stereoisomers using chromatographic, spectroscopic, and chiroptical methods.

The authors then present an overview of the most important methods in contemporary asymmetric synthesis organized by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions, one chapter on reductions, and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). This organization allows the reader to compare the leading methods for asymmetric synthesis in an appropriate context.

A highlight of the book is the presentation and discussion of transition states at the current level of understanding, for important reaction types. In addition, extensive tables of examples are used to give the reader an appreciation for the scope of each reaction. Finally, leading references are provided to natural product synthesis that has been accomplished using a given reaction as a key step.

More books from Elsevier Science

Cover of the book Sun Power by Robert E. Gawley, Jeffrey Aube
Cover of the book Science and Technology of Fruit Wine Production by Robert E. Gawley, Jeffrey Aube
Cover of the book Hormones, Lipoproteins and Atherosclerosis by Robert E. Gawley, Jeffrey Aube
Cover of the book Soil Pollution by Robert E. Gawley, Jeffrey Aube
Cover of the book Handbook of Traffic Psychology by Robert E. Gawley, Jeffrey Aube
Cover of the book Fluid-Structure Interactions by Robert E. Gawley, Jeffrey Aube
Cover of the book Critical Care Neurology Part II by Robert E. Gawley, Jeffrey Aube
Cover of the book Lockhart and Wiseman’s Crop Husbandry Including Grassland by Robert E. Gawley, Jeffrey Aube
Cover of the book Wireless Communications Design Handbook by Robert E. Gawley, Jeffrey Aube
Cover of the book Gibbs' Entropic Paradox and Problems of Separation Processes by Robert E. Gawley, Jeffrey Aube
Cover of the book Treatise on Water Science by Robert E. Gawley, Jeffrey Aube
Cover of the book Genomic Control Process by Robert E. Gawley, Jeffrey Aube
Cover of the book Numerical Modelling of Wave Energy Converters by Robert E. Gawley, Jeffrey Aube
Cover of the book Ring Theory, 83 by Robert E. Gawley, Jeffrey Aube
Cover of the book Neural Networks in Finance by Robert E. Gawley, Jeffrey Aube
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy