Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology

Nonfiction, Science & Nature, Science, Biological Sciences, Cytology, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461458944
Publisher: Springer New York Publication: November 19, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781461458944
Publisher: Springer New York
Publication: November 19, 2012
Imprint: Springer
Language: English

​​​​​​​Prominin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research. The primary audience for this book is geared towards scientists and researchers with interest in cancer stem cells, stem cells, cell biology, neurobiology, and regenerative medicine.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

​​​​​​​Prominin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research. The primary audience for this book is geared towards scientists and researchers with interest in cancer stem cells, stem cells, cell biology, neurobiology, and regenerative medicine.

More books from Springer New York

Cover of the book Bioarchaeology by
Cover of the book Feedback Strategies for Wireless Communication by
Cover of the book Conservation of Tropical Plant Species by
Cover of the book Encapsulation Technologies for Active Food Ingredients and Food Processing by
Cover of the book Imaging of the Cervical Spine in Children by
Cover of the book Operations Research and Health Care Policy by
Cover of the book Universities in Change by
Cover of the book Wild Salmonids in the Urbanizing Pacific Northwest by
Cover of the book Ultrasonography of Muscles and Tendons by
Cover of the book Subunit Vaccine Delivery by
Cover of the book Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems by
Cover of the book Methylmercury and Neurotoxicity by
Cover of the book Residue Reviews by
Cover of the book Clusters, Orders, and Trees: Methods and Applications by
Cover of the book Tropical Meteorology by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy