TRAIL, Fas Ligand, TNF and TLR3 in Cancer

Nonfiction, Health & Well Being, Medical, Specialties, Oncology
Cover of the book TRAIL, Fas Ligand, TNF and TLR3 in Cancer by , Springer International Publishing
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Author: ISBN: 9783319568058
Publisher: Springer International Publishing Publication: July 3, 2017
Imprint: Springer Language: English
Author:
ISBN: 9783319568058
Publisher: Springer International Publishing
Publication: July 3, 2017
Imprint: Springer
Language: English

This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic targets for cancer therapy. But an increasing body of evidence suggests that some of these receptors may also contribute to tumorigenesis, or that new players such as TLR3 may be targeted for cancer therapy due to their ability to behave like death receptors.

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This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic targets for cancer therapy. But an increasing body of evidence suggests that some of these receptors may also contribute to tumorigenesis, or that new players such as TLR3 may be targeted for cancer therapy due to their ability to behave like death receptors.

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