Innate Tolerance in the CNS

Translational Neuroprotection by Pre- and Post-Conditioning

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Neuroscience, Neurology, Science & Nature, Science
Cover of the book Innate Tolerance in the CNS by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781441996954
Publisher: Springer New York Publication: September 21, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781441996954
Publisher: Springer New York
Publication: September 21, 2012
Imprint: Springer
Language: English

Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.

More books from Springer New York

Cover of the book Multiple Criteria Decision Analysis by
Cover of the book Discovering and Developing Molecules with Optimal Drug-Like Properties by
Cover of the book Monte Carlo Statistical Methods by
Cover of the book New Perspectives on Old Stones by
Cover of the book Wrist and Elbow Arthroscopy by
Cover of the book Lung Cancer Imaging by
Cover of the book Functional Equations in Mathematical Analysis by
Cover of the book Famous First Papers for the Neurointensivist by
Cover of the book From Mars to Greenland: Charting Gravity With Space and Airborne Instruments by
Cover of the book Gaither's Dictionary of Scientific Quotations by
Cover of the book Epidemiology and Biostatistics by
Cover of the book Fundamentals of Family Medicine by
Cover of the book Neuroscience for Clinicians by
Cover of the book Flags of the Night Sky by
Cover of the book Evaluation and Management of Blepharoptosis by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy