Microglia in Neurodegenerative Diseases

Role of TTP in classical and alternative microglia activation pathway

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Neurology
Cover of the book Microglia in Neurodegenerative Diseases by Simon Schwörer, GRIN Verlag
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Simon Schwörer ISBN: 9783656158493
Publisher: GRIN Verlag Publication: March 23, 2012
Imprint: GRIN Verlag Language: English
Author: Simon Schwörer
ISBN: 9783656158493
Publisher: GRIN Verlag
Publication: March 23, 2012
Imprint: GRIN Verlag
Language: English

Internship Report from the year 2012 in the subject Medicine - Neurology, Psychiatry, Addiction, grade: 1,0, University of Ulm (Experimentelle Neurologie), language: English, abstract: Microglia activation plays a crucial role in neurodegenerative diseases. There are at least two distinct ways of microglia activation, the classical lipopolysaccharide (LPS) induced pathway leading to secretion of pro-inflammatory cytokines and inflammation as well as the alternative interleukin-4 (IL-4) induced pathway resulting in increased wound healing and tissue repair (Figure 1). It is known that the anti-inflammatory alternative pathway is competent to dampen the inflammatory effects of the classical microglia activation, as IL-6 and tumor necrosis factor-? (TNF-?) levels of LPS-stimulated microglia were remarkably reduced after additional excitation of the alternative activation of microglia. This effect could be achieved by the use of particular RNA binding proteins. An example for such RNA binding proteins would be tristetraprolin (TTP). TTP is binding to AU-rich elements (ARE) in the 3' untranslated region of mRNA molecules and promotes decay of ARE-containing transcripts by directing them to the exosome for rapid mRNA degradation. The aim of the practical research course was to ascertain a possible participation of TTP in the IL-4 induced alternative activation of microglia, thereby potentially explaining the dampening effect on the inflammatory pathway.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Internship Report from the year 2012 in the subject Medicine - Neurology, Psychiatry, Addiction, grade: 1,0, University of Ulm (Experimentelle Neurologie), language: English, abstract: Microglia activation plays a crucial role in neurodegenerative diseases. There are at least two distinct ways of microglia activation, the classical lipopolysaccharide (LPS) induced pathway leading to secretion of pro-inflammatory cytokines and inflammation as well as the alternative interleukin-4 (IL-4) induced pathway resulting in increased wound healing and tissue repair (Figure 1). It is known that the anti-inflammatory alternative pathway is competent to dampen the inflammatory effects of the classical microglia activation, as IL-6 and tumor necrosis factor-? (TNF-?) levels of LPS-stimulated microglia were remarkably reduced after additional excitation of the alternative activation of microglia. This effect could be achieved by the use of particular RNA binding proteins. An example for such RNA binding proteins would be tristetraprolin (TTP). TTP is binding to AU-rich elements (ARE) in the 3' untranslated region of mRNA molecules and promotes decay of ARE-containing transcripts by directing them to the exosome for rapid mRNA degradation. The aim of the practical research course was to ascertain a possible participation of TTP in the IL-4 induced alternative activation of microglia, thereby potentially explaining the dampening effect on the inflammatory pathway.

More books from GRIN Verlag

Cover of the book Daniel Spoerri (Fallenbild) - Unterrichtsentwurf by Simon Schwörer
Cover of the book Unterrichtseinheit: Was Luft alles kann - Erfinder bei der Arbeit by Simon Schwörer
Cover of the book Rekonstruktion des Teilbarkeitsarguments in Descartes´ Meditationes de Prima Philosophia by Simon Schwörer
Cover of the book Was versteht man unter Zivil- bzw. Bürgergesellschaft und welche Rolle kommt dem 'Dritten Sektor' dabei zu? by Simon Schwörer
Cover of the book Der Begriff der Erfahrung und seine Verbindung zum Lernen nach John Dewey by Simon Schwörer
Cover of the book Bildungschancen und Bildungsungleichheiten in Deutschland in Bezug auf die Theorie des Kapitals von Pierre Bourdieu by Simon Schwörer
Cover of the book Erziehung und Bildung im Nationalsozialismus by Simon Schwörer
Cover of the book Zwangsstörung - Begriffsklärung, Ursachen, Behandlungsmöglichkeiten by Simon Schwörer
Cover of the book Is it more accurate to speak of the collapse or the destruction of the Weimar Republic by Simon Schwörer
Cover of the book Das Bildungssystem in Frankreich by Simon Schwörer
Cover of the book Der Schlüssel zum Erfolg: Zielführend kommunizieren by Simon Schwörer
Cover of the book Entwurf und Implementierung eines Systems für Mehrpersonenspiele mit JINI und JavaSpaces by Simon Schwörer
Cover of the book Transformational Leadership and Ethical Values. A Philosophical Approach by Simon Schwörer
Cover of the book Ehe versus Liebe in 'De amore libri tres' und im Kontext der höfischen Liebe by Simon Schwörer
Cover of the book Bildungs- und kommunikationswissenschaftliche Voraussetzungen für den Einsatz von neuen Lehr- und Lernformen by Simon Schwörer
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy