Microglia in Neurodegenerative Diseases

Role of TTP in classical and alternative microglia activation pathway

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Neurology
Cover of the book Microglia in Neurodegenerative Diseases by Simon Schwörer, GRIN Verlag
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Simon Schwörer ISBN: 9783656158493
Publisher: GRIN Verlag Publication: March 23, 2012
Imprint: GRIN Verlag Language: English
Author: Simon Schwörer
ISBN: 9783656158493
Publisher: GRIN Verlag
Publication: March 23, 2012
Imprint: GRIN Verlag
Language: English

Internship Report from the year 2012 in the subject Medicine - Neurology, Psychiatry, Addiction, grade: 1,0, University of Ulm (Experimentelle Neurologie), language: English, abstract: Microglia activation plays a crucial role in neurodegenerative diseases. There are at least two distinct ways of microglia activation, the classical lipopolysaccharide (LPS) induced pathway leading to secretion of pro-inflammatory cytokines and inflammation as well as the alternative interleukin-4 (IL-4) induced pathway resulting in increased wound healing and tissue repair (Figure 1). It is known that the anti-inflammatory alternative pathway is competent to dampen the inflammatory effects of the classical microglia activation, as IL-6 and tumor necrosis factor-? (TNF-?) levels of LPS-stimulated microglia were remarkably reduced after additional excitation of the alternative activation of microglia. This effect could be achieved by the use of particular RNA binding proteins. An example for such RNA binding proteins would be tristetraprolin (TTP). TTP is binding to AU-rich elements (ARE) in the 3' untranslated region of mRNA molecules and promotes decay of ARE-containing transcripts by directing them to the exosome for rapid mRNA degradation. The aim of the practical research course was to ascertain a possible participation of TTP in the IL-4 induced alternative activation of microglia, thereby potentially explaining the dampening effect on the inflammatory pathway.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Internship Report from the year 2012 in the subject Medicine - Neurology, Psychiatry, Addiction, grade: 1,0, University of Ulm (Experimentelle Neurologie), language: English, abstract: Microglia activation plays a crucial role in neurodegenerative diseases. There are at least two distinct ways of microglia activation, the classical lipopolysaccharide (LPS) induced pathway leading to secretion of pro-inflammatory cytokines and inflammation as well as the alternative interleukin-4 (IL-4) induced pathway resulting in increased wound healing and tissue repair (Figure 1). It is known that the anti-inflammatory alternative pathway is competent to dampen the inflammatory effects of the classical microglia activation, as IL-6 and tumor necrosis factor-? (TNF-?) levels of LPS-stimulated microglia were remarkably reduced after additional excitation of the alternative activation of microglia. This effect could be achieved by the use of particular RNA binding proteins. An example for such RNA binding proteins would be tristetraprolin (TTP). TTP is binding to AU-rich elements (ARE) in the 3' untranslated region of mRNA molecules and promotes decay of ARE-containing transcripts by directing them to the exosome for rapid mRNA degradation. The aim of the practical research course was to ascertain a possible participation of TTP in the IL-4 induced alternative activation of microglia, thereby potentially explaining the dampening effect on the inflammatory pathway.

More books from GRIN Verlag

Cover of the book Bildung und Erziehung in einer modernen Gesellschaft. Überlegungen von Émile Durkheim by Simon Schwörer
Cover of the book Humor and Its Pursued Strategies in 'Smoke Signals' (1998) by Simon Schwörer
Cover of the book Rechtsextremismus in Frankreich: Der Front National als Partei der goldenen Mitte? by Simon Schwörer
Cover of the book Sportgeschmack als Distinktionsmittel bei älteren Menschen by Simon Schwörer
Cover of the book Suchmaschinenoptimierung by Simon Schwörer
Cover of the book Personalführung. Einblick in Führungsprozesse und -stile by Simon Schwörer
Cover of the book Positive Jugendentwicklung und Prävention by Simon Schwörer
Cover of the book Chaos oder alles unter Kontrolle? - Mediennutzung von Jugendlichen im Wandel by Simon Schwörer
Cover of the book Kundenbindungsmanagement. Kundenzufriedenheitsanalyse und Ableitung von Handlungsempfehlungen zur Steigerung der Kundenbindung by Simon Schwörer
Cover of the book Kuba. Ein kommunistisch-totalitäres Regime? by Simon Schwörer
Cover of the book Verhaltensorientierung im Controlling by Simon Schwörer
Cover of the book Probleme des Übersetzens: Literarische Übersetzungen. Beispiele aus den Sprachen: Deutsch, Französisch und Englisch by Simon Schwörer
Cover of the book Einflüsse auf die Ausbildung politischen Interesses by Simon Schwörer
Cover of the book Die postalische Befragung - Methodische Probleme und Lösungsansätze by Simon Schwörer
Cover of the book Blind und sehend in einer Person by Simon Schwörer
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy